Social determinants of health (SDOH) are nonmedical factors (e.g., poverty) that have an influence on health and development. Early childhood education settings, such as preschools, play a dual role in children’s well-being; high quality is considered both a social determinant of health and a context for receiving referrals to address other SDOH. The current study examines reports of SDOH among a sample of 139 preschool teachers recruited from a Mountain West state. Reported prevalence of SDOH were rated as higher by teachers with more familiarity with SDOH, teachers in public/Head Start schools (vs. private schools), and assistant teachers (vs. lead teachers). Teachers who were more familiar with SDOH and who reported a higher prevalence of SDOH in their classrooms were more likely to refer students to resources to address SDOH. (author abstract)