This brief aims to provide information on Indigenous Peoples in the United States (U.S.) and U.S. territories for those who fund and conduct research, evaluation, and technical assistance. The brief is not only for those with experience engaging with Indigenous Peoples in these activities, but also for those seeking to engage with and fund Indigenous work. We hope that, with this guidance, individuals and organizations who work with Indigenous children, youth, and families—and those who fund this work—can begin to counteract the impacts of colonization, inadequate and/or harmful federal policies, and research abuses. (author abstract)