In 2012, the Annie E. Casey Foundation began searching for partners for its seven-year Family-Centered Community Change™(FCCC) initiative. This report reviews the Foundation’s experiences and contributions as an investor and summarizes what the participating communities — Buffalo, New York; Columbus, Ohio; and San Antonio, Texas — learned about using a two-generation approach to working with children and parents. FCCC is a place-based strategy devoted to improving outcomes for children and parents living in high-poverty neighborhoods. The initiative works to bolster family well-being in three key areas: 1) economic stability; 2) parent engagement and leadership; and 3) early child care and education. (author abstract)