Past research on cross-platform learning indicates that combined use of multiple media can produce greater learning than a single media component. However, designing transmedia materials effectively for cross-platform learning presents challenges beyond those of traditional production within a single medium. This paper discusses several approaches to production and instructional design that were employed in Ready to Learn projects in 2010-2015, to provide insight into the inherent challenges and opportunities. We differentiate between approaches that rely upon either legacy content or original intellectual properties, present a case study of the production of UMIGO, and identify factors that contribute to blending video and interactivity effectively to promote cross-platform learning. (author abstract)