This handbook of procedures and standards is a transparent account of how the HomVEE review operates. As noted, this is the second version of HomVEE’s procedures and standards, and it updates the version initially published on the HomVEE website. This first chapter gives some background about HomVEE, including the scope of the review and definitions of key terms (Exhibits I.1 and I.4). Chapter II describes the evidence review process, including how HomVEE (1) identifies eligible research and prioritizes models for review, (2) rates the quality of impact research and assesses whether the model is evidence based, and (3) reports results on the model’s impact and implementation. Chapter III describes the standards for rating research quality, and how HomVEE applies those standards to rate the quality of impact research. Technical details about the procedures and standards are in the appendices. (author abstract)