On April 17-18, OPRE held the meeting "The Way Forward: ACF Research with American Indians and Alaska Natives" at the National Museum of the American Indian. Over sixty researchers and federal staff who do research with AIAN communities gathered to learn about the current state of ACF research in tribal communities and to discuss future directions. From Tribal Health Profession Opportunity Grants to Tribal Maternal Infant Early Childhood Home Visiting, participants engaged in a lively discussion regarding how best to build knowledge that can increase understanding and help inform decision-making in tribal communities. The meeting was structured over two days to highlight important topics through a series of presentations including: principles of engagement when collaborating with AIAN communities in research; supporting research capacity in AIAN communities; community engagement in measurement development; challenges of using existing measures in AIAN communities; and designing and scaling interventions from a cross-cultural perspective and thinking beyond randomized control trials to consider other rigorous designs when collaborating with AIAN communities. After each presentation, discussants representing the broad range of stakeholders present commented on the topic and presentations, then facilitators invited commentary from all the attendees. (author abstract)