Preschool Development Grants (PDG) are funded to provide high-quality preschool education and comprehensive services to support four-year-olds and their families who are living at or below 200% of federal poverty. At the same time, Head Start is funded to offer high-quality preschool and comprehensive services to children living with families with income at or below federal poverty levels. The overlap between these two programs presents a unique opportunity for PDG and Head Start to form mutually beneficial partnerships. There are both opportunities and challenges in implementing programs to meet both the Head Start and PDG standards. Issues of standards, program requirements and policies, personnel, and budgeting reflect just a few of the partnership elements that confront programs. Many PDG states have successfully worked through these partnership components. This document will highlight the opportunities PDG/Head Start partnerships can provide. The brief provides descriptions of collaborations within states that received PDG awards along with information on the strategies states can use to successfully work through the issues these partnerships face. (author abstract)